Akiharu Kubo Selected Research

Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)

1/2022	Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease.
7/2017	Novel nonsense mutation in SERPINB7 and the treatment of foot odor in a patient with Nagashima-type palmoplantar keratosis.
8/2014	Nagashima-type palmoplantar keratosis: a common Asian type caused by SERPINB7 protease inhibitor deficiency.
11/2013	Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.

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Akiharu Kubo Research Topics

Disease

8	Atopic Dermatitis (Atopic Eczema) 02/2021 - 05/2009
4	Dermatitis 01/2022 - 05/2010
4	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 01/2022 - 11/2013
4	Skin Diseases (Skin Disease) 01/2022 - 01/2011
2	Hypersensitivity (Allergy) 01/2022 - 11/2018
2	Blister (Bulla) 09/2021 - 08/2013
2	Inflammation (Inflammations) 01/2015 - 05/2009
2	Eczema 11/2013 - 05/2009
2	Contact Dermatitis (Eczema, Contact) 06/2012 - 05/2010
2	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris) 01/2011 - 05/2009
2	Asthma (Bronchial Asthma) 01/2011 - 05/2009
1	Ichthyosis (Xeroderma) 11/2022
1	Autoimmune progesterone dermatitis 10/2022
1	Keratosis 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 09/2021
1	Linear IgA Bullous Dermatosis 09/2021
1	Rare Diseases (Rare Disease) 09/2021
1	Familial acanthosis nigricans 08/2021
1	Porokeratosis (Palmoplantar Porokeratosis) 12/2019
1	Chondrodysplasia Punctata (Stippled Epiphyses) 01/2019
1	Infections 11/2018
1	Netherton Syndrome 11/2018
1	Keratitis, Ichthyosis, and Deafness (KID) Syndrome 11/2018
1	Acanthosis Nigricans 10/2017
1	Hidradenitis Suppurativa 08/2017
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2016
1	Rheumatoid Arthritis 01/2016
1	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 05/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2013
1	Hereditary Corneal Dystrophies 07/2013
1	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) 07/2013
1	Psoriasis (Pustulosis Palmaris et Plantaris) 03/2012
1	Allergic Contact Dermatitis 03/2012
1	Staphylococcal Scalded Skin Syndrome (Ritter's Disease) 12/2011
1	Allergic Rhinitis 01/2011
1	Psychotic Disorders (Schizoaffective Disorder) 09/2008
1	Schizophrenia (Dementia Praecox) 09/2008
1	Bardet-Biedl syndrome 4 09/2008

Drug/Important Bio-Agent (IBA)

7	Filaggrin ProteinsIBA 01/2020 - 05/2009
7	AntigensIBA 01/2015 - 05/2009
5	Nonsense Codon (Nonsense Mutation)IBA 08/2021 - 09/2008
5	Proteins (Proteins, Gene)FDA Link 11/2013 - 09/2008
3	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2022 - 11/2013
3	HaptensIBA 01/2015 - 05/2010
3	Immunoglobulin E (IgE)IBA 06/2012 - 05/2009
1	loricrinIBA 11/2022
1	dienogest FDA Link 10/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	Desmoglein 1IBA 01/2022
1	DesmogleinsIBA 01/2022
1	AutoantibodiesIBA 09/2021
1	Immunoglobulin A (IgA)IBA 09/2021
1	Secretory Immunoglobulin A (SIgA)IBA 09/2021
1	NucleotidesIBA 02/2021
1	EnzymesIBA 12/2019
1	Mevalonic Acid (Mevalonate)IBA 12/2019
1	AllergensIBA 11/2018
1	glycolic acid (glycolate)IBA 10/2017
1	Biological ProductsIBA 01/2016
1	Methotrexate (Mexate)FDA LinkGeneric 01/2016
1	tenascin XIBA 05/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Protease Inhibitors (Protease Inhibitor)IBA 08/2014
1	Keratins (Keratin)IBA 07/2013
1	Irritants (Vesicants)IBA 06/2012
1	Immunoglobulin G (IgG)IBA 06/2012
1	OvalbuminIBA 06/2012

Therapy/Procedure

1	Negative-Pressure Wound Therapy 08/2017